Morphological and flowability study of some drugs

phenobarbitone and α-methyldopa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Morphological and powder rheological parameters of phenobarbitone and α-methyldopa were tested. The habits of the crystals were investigated by scanning electron microscopy (SEM). Particle size distribution was tested with an image analysis system. The rearrangement factors (k), the compactibility and the cohesiveness of the crystals were calculated from the loose and tapped volumes of the drugs. It was concluded that the habits of the tested drugs were different, as were the particle sizes and the particle size distributions. These properties influence the rearrangement of the particles. Finally, it was established that the powder rheological parameters of phenobarbitone are better than those of α-methyldopa.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalHungarian Journal of Industrial Chemistry
Volume27
Issue number3
Publication statusPublished - 1999

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Methyldopa
Phenobarbital
Particle size analysis
Powders
Crystals
Pharmaceutical Preparations
Image analysis
Particle size
Scanning electron microscopy

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Chemistry (miscellaneous)

Cite this

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title = "Morphological and flowability study of some drugs: phenobarbitone and α-methyldopa",
abstract = "Morphological and powder rheological parameters of phenobarbitone and α-methyldopa were tested. The habits of the crystals were investigated by scanning electron microscopy (SEM). Particle size distribution was tested with an image analysis system. The rearrangement factors (k), the compactibility and the cohesiveness of the crystals were calculated from the loose and tapped volumes of the drugs. It was concluded that the habits of the tested drugs were different, as were the particle sizes and the particle size distributions. These properties influence the rearrangement of the particles. Finally, it was established that the powder rheological parameters of phenobarbitone are better than those of α-methyldopa.",
author = "M. Siaan and K. Pintye-H{\'o}di and P. Szab{\'o}-R{\'e}v{\'e}sz and P. K{\'a}sa and I. Er{\"o}s",
year = "1999",
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journal = "Hungarian Journal of Industrial Chemistry",
issn = "0133-0276",
publisher = "University of Veszprem",
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TY - JOUR

T1 - Morphological and flowability study of some drugs

T2 - phenobarbitone and α-methyldopa

AU - Siaan, M.

AU - Pintye-Hódi, K.

AU - Szabó-Révész, P.

AU - Kása, P.

AU - Erös, I.

PY - 1999

Y1 - 1999

N2 - Morphological and powder rheological parameters of phenobarbitone and α-methyldopa were tested. The habits of the crystals were investigated by scanning electron microscopy (SEM). Particle size distribution was tested with an image analysis system. The rearrangement factors (k), the compactibility and the cohesiveness of the crystals were calculated from the loose and tapped volumes of the drugs. It was concluded that the habits of the tested drugs were different, as were the particle sizes and the particle size distributions. These properties influence the rearrangement of the particles. Finally, it was established that the powder rheological parameters of phenobarbitone are better than those of α-methyldopa.

AB - Morphological and powder rheological parameters of phenobarbitone and α-methyldopa were tested. The habits of the crystals were investigated by scanning electron microscopy (SEM). Particle size distribution was tested with an image analysis system. The rearrangement factors (k), the compactibility and the cohesiveness of the crystals were calculated from the loose and tapped volumes of the drugs. It was concluded that the habits of the tested drugs were different, as were the particle sizes and the particle size distributions. These properties influence the rearrangement of the particles. Finally, it was established that the powder rheological parameters of phenobarbitone are better than those of α-methyldopa.

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VL - 27

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