Morphologic, biologic, and cytochemical analysis of intracytoplasmic particles found in cultured fibroblasts from patients with systemic lupus erythematosus

D. W. Barry, Z. Schaff, P. M. Grimley, H. E. Hopps, R. Aptekar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fibroblasts grown from one involved and 7 uninvolved skin sites of patients with systemic lupus erythematosus (SLE), 2 patients with rheumatoid arthritis (RA), and one normal patient were examined by light, fluorescent, and electron microscopy. All failed to show evidence of virus like particles or tubuloreticular structures previously observed in the endoplasmic reticulum of tissue from patients with SLE. Densely staining intracellular punctate bodies 250-500 Å in diameter were tentatively identified by differential cytochemical staining as glycogen granules. Cultures from normal, SLE, and RA patients showed identical susceptibility to infection with Newcastle disease virus.

Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalJournal of Investigative Dermatology
Volume63
Issue number5
Publication statusPublished - 1974

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Fibroblasts
Viruses
Systemic Lupus Erythematosus
Glycogen
Electron microscopy
Skin
Tissue
Rheumatoid Arthritis
Staining and Labeling
Newcastle disease virus
Endoplasmic Reticulum
Virion
Electron Microscopy
Light
Infection

ASJC Scopus subject areas

  • Dermatology

Cite this

Morphologic, biologic, and cytochemical analysis of intracytoplasmic particles found in cultured fibroblasts from patients with systemic lupus erythematosus. / Barry, D. W.; Schaff, Z.; Grimley, P. M.; Hopps, H. E.; Aptekar, R.

In: Journal of Investigative Dermatology, Vol. 63, No. 5, 1974, p. 407-410.

Research output: Contribution to journalArticle

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