Morphologic, biologic, and cytochemical analysis of intracytoplasmic particles found in cultured fibroblasts from patients with systemic lupus erythematosus

D. W. Barry, Z. Schaff, P. M. Grimley, H. E. Hopps, R. Aptekar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fibroblasts grown from one involved and 7 uninvolved skin sites of patients with systemic lupus erythematosus (SLE), 2 patients with rheumatoid arthritis (RA), and one normal patient were examined by light, fluorescent, and electron microscopy. All failed to show evidence of virus like particles or tubuloreticular structures previously observed in the endoplasmic reticulum of tissue from patients with SLE. Densely staining intracellular punctate bodies 250-500 Å in diameter were tentatively identified by differential cytochemical staining as glycogen granules. Cultures from normal, SLE, and RA patients showed identical susceptibility to infection with Newcastle disease virus.

Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalUnknown Journal
Volume63
Issue number5
DOIs
Publication statusPublished - Jan 1 1974

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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