Morfológiai és biokémiai elváltozások akut experimentális interstitialis pancreatitisben.

Translated title of the contribution: Morphologic and biochemical changes in acute experimental interstitial pancreatitis

Z. Lászik, Z. Berger, A. Pap

Research output: Contribution to journalArticle

Abstract

Repeated subcutaneous injections of cholecystokinin-octapeptide has brought about an acute interstitial pancreatitis in rats. The aim of the experiment was the study of histological and biochemical alterations with special regard to regeneration phenomena. The treatment was carried out for 1 (group 1), 3,5 and 7 (group 2) days. Morphological alterations were more pronounced in group 2 than in group 1, but the pathological process was principally similar in both groups. Lowest values of pancreatic weight, protein and DNA content were attained in both groups at day 5. After this, protein and DNA started to increase. Hyperstimulation with CCK-OP on day 5 did not increase the degree of pancreas damage, nor did it prevent morphological and functional regeneration. The reason of this may be the decreased CCK-OP sensitivity of pancreatic acinar cells and/or the increased CCK-OP tolerance of newly formed acinar cells.

Original languageHungarian
Pages (from-to)89-97
Number of pages9
JournalMorphologiai es Igazsagugyi Orvosi Szemle
Volume29
Issue number2
Publication statusPublished - Apr 1 1989

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ASJC Scopus subject areas

  • Medicine(all)

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