Morphine tolerance in mice is independent of polymorphisms in opioid receptor sequences

Tracey Michele Gant, P. Riba, Nancy M. Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pharmacogenomics links individual drug response variation to genetic differences, such as single nucleotide polymorphisms (SNPs). In particular, pharmacogenomics will allow clinicians to use genetic diagnostics to predict the response of a patient to a drug. We investigated whether SNPs in opioid receptors correlated with the development of morphine tolerance in mouse strains that showed either high or low tolerance to morphine. Sequencing identified five silent SNPs in the δ opioid receptor that varied from the published sequence in some strains, but which were found in both high and low tolerance strains. The μ and κ opioid receptor sequences had no SNPs. Taken together, these data definitively demonstrate that morphine tolerance development in mice is independent of opioid receptor sequence.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalBrain Research Bulletin
Volume55
Issue number1
DOIs
Publication statusPublished - May 1 2001

Fingerprint

Opioid Receptors
Morphine
Single Nucleotide Polymorphism
Pharmacogenetics
Pharmaceutical Preparations

Keywords

  • Morphine
  • Opioid receptor
  • SNP
  • Tolerance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Morphine tolerance in mice is independent of polymorphisms in opioid receptor sequences. / Gant, Tracey Michele; Riba, P.; Lee, Nancy M.

In: Brain Research Bulletin, Vol. 55, No. 1, 01.05.2001, p. 59-63.

Research output: Contribution to journalArticle

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