Morphine tolerance and withdrawal in capsaicin - - pretreated rats

margit Szikszay, G. Benedek, F. Obál

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Thermoregulatory reactions to warm exposure and naloxone treatment, as well as behavioural reactions to morphine withdrawal, were recorded in morphine tolerant rats after capsaicin pretreatment. Enhanced behavioural reactions to morphine withdrawal were found in capsaicin pretreated rats, although no differences in degree of withdrawal hypothermia were seen. Morphine tolerant rats displayed increased thermal tolerance; this was partially prevented by capsaicin pretreatment. The results provide further evidence concerning the interference of neural mechanisms sensitive to capsaicin and opiates.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalLife Sciences
Issue numberSUPPL. 1
Publication statusPublished - 1983


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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