Morphine potentiates the gastroulcerogenic effect of indometacin in rats

Klára Gyires, Susanna Fürst, Eniko Farczádi, Andrea Márton

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Morphine potentiated the ulcerogenic activity of indometacin in a dose-dependent manner when administered subcutaneously (2.5-7.5 mg/kg). However, in the case of intracerebroventricular administration, morphine failed to exert any potentiating action. Atropine (0.5 mg/kg, s.c.) and cimetidine (12.5-25 mg/kg, s.c.) decreased the ulcerogenic activity of indometacin, and the combination of indometacin/morphine in about the same degree. However, the reduced ulcerogenic activity of indometacin after atropine or cimetidine treatment could still be enhanced by morphine if it was added to the combination of indometacin/atropine or indometacin/cimetidine. Since the potentiating action of morphine was completely blocked by naloxone (1 mg/kg), this action of morphine might be mediated via opiate receptors.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalPharmacology
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 1 1985

Keywords

  • Atropine
  • Cimetidine
  • Gastric mucosal damage
  • Morphine
  • Naloxone
  • Rat

ASJC Scopus subject areas

  • Pharmacology

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