Morphine inhibits the carrageenan‐induced oedema and the chemoluminescence of leucocytes stimulated by zymosan

KLÁRA GYIRES, I. BUDAVÁRI, S. FÜRST, I. MOLNÁR

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Abstract

Morphine inhibited the oedema formation induced by carrageenan. The anti‐inflammatory activity developed 120 min after carrageenan injection, suggesting that inhibition of the kinin phase might be partly responsible. This assumption is supported by the findings that morphine inhibited bradykinin oedema but did not influence oedema formation induced by histamine, 5‐HT or PGE2. The anti‐inflammatory activity of morphine was partially inhibited by naloxone (0.5−1 mg kg−1) in the carrageenan oedema test. Zymosanstimulated chemoluminescence of neutrophils of the rat was inhibited both by morphine (0.1‐10 μM) and naloxone (1‐100 μM). When morphine and naloxone were administered simultaneously (10 μM) their inhibitory effects were additive. Naloxone also failed to antagonize the inhibitory action of morphine in lower dose (0.1 μM). These results suggest that the effect of morphine in inflammation might be mediated either by one of the opiate receptor subtypes insensitive to naloxone or a non‐opiate mechanism might be involved. 1985 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume37
Issue number2
DOIs
Publication statusPublished - Feb 1985

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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