Monophosphoryl lipid A reduces both arrhythmia severity and infarct size in a rat model of ischaemia

Wu Song, Brian L. Furman, James R. Parratt

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A non-toxic derivative of the active lipid A component of the endotoxin molecule (monophosphoryl lipid A) when given to rats in a dose of 5 mg kg- 1 by intraperitoneal injection 24 h prior to anaesthesia and coronary artery occlusion, markedly decreased the severity of ischaemia-reduced ventricular arrhythmias (ventricular fibrillation reduced from 60 to 21%; P < 0.05) and reduced myocardial infarct size (from 35.8 ± 1.6% of the area at risk to 22.7 ± 2.0%; P < 0.05). It did not modify blood pressure or heart rate either before or during the period of ischaemia.

Original languageEnglish
Pages (from-to)285-287
Number of pages3
JournalEuropean Journal of Pharmacology
Volume345
Issue number3
DOIs
Publication statusPublished - Mar 26 1998

Keywords

  • Infarct size
  • Ischaemic preconditioning
  • Monophosphoryl lipid A
  • Myocardial ischaemia
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Pharmacology

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