Monoclonal antibodies to the hydrogenase of Thiocapsa roseopersicina

Gábor J. Tigyi, Kornél L. Kovács

Research output: Contribution to journalArticle

2 Citations (Scopus)


Monoclonal antibodies were produced to electrophoretically pure hydrogenase from Thiocapsa roseopersicina. Protein immunoelectroblotting was used to identify the hydrogenase-specific antibodies. Among the 18 monoclonal antibodies selected by enzyme immunoassay, three were found to react with highly immunogenic trace contaminating proteins. One cell line produced antibody that inhibitied hydrogenase activity. This was the first specific inhibitor of the hydrogenase function. The results suggest that monoclonal antibodies could provide valuable new informations about the enzyme structure as well.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalCurrent Microbiology
Issue number6
Publication statusPublished - Nov 1 1984

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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