Mono- versus binuclear copper(II) complexes in phosphodiester hydrolysis

Katalin Selmeczi, Michel Giorgi, G. Speier, E. Farkas, Marius Réglier

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Mono- and dinuclear copper(II) complexes [Cu(L1OH)]-(CF 3SO3)2 (1) and [Cu2(L 2O)](CF3SO3)3 (2) have been synthesized and characterized by X-ray crystallography. Complexes 1 and 2 were then tested as catalysts for the hydrolysis of bis(p-nitrophenyl)phosphate (BNPP). At pH 6, the dinuclear complex 2 was found to be 20-fold more active than complex 1 and the reaction up to 600-fold faster than the un-promoted reaction. On the basis of potentiometric studies, we were able to demonstrate that the bis(aqua)copper complex was the active species by the formation of a ternary complex in which one copper atom binds to a hydroxide and the second, to the substrate. We also propose that BNPP reacts with the bis(aqua)copper complex to give a stable, hydrolytically inactive BNPP-2 complex (3).

Original languageEnglish
Pages (from-to)1022-1031
Number of pages10
JournalEuropean Journal of Inorganic Chemistry
Issue number5
DOIs
Publication statusPublished - Mar 6 2006

Fingerprint

Copper
Hydrolysis
X ray crystallography
Atoms
Catalysts
Substrates
bis(4-nitrophenyl)phosphate

Keywords

  • Catalysis
  • Dinuclear copper(II) complex
  • Enzyme mimics
  • Phosphate ester hydrolysis
  • Tripodal ligands

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Mono- versus binuclear copper(II) complexes in phosphodiester hydrolysis. / Selmeczi, Katalin; Giorgi, Michel; Speier, G.; Farkas, E.; Réglier, Marius.

In: European Journal of Inorganic Chemistry, No. 5, 06.03.2006, p. 1022-1031.

Research output: Contribution to journalArticle

Selmeczi, Katalin ; Giorgi, Michel ; Speier, G. ; Farkas, E. ; Réglier, Marius. / Mono- versus binuclear copper(II) complexes in phosphodiester hydrolysis. In: European Journal of Inorganic Chemistry. 2006 ; No. 5. pp. 1022-1031.
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