Monitoring urinary orosomucoid in patients undergoing cardiac surgery

A promising novel inflammatory marker

Péter Kustán, Balázs Szirmay, T. Kőszegi, Andrea Ludány, G. Kovács, A. Miseta, Diána Mühl, Balázs Németh, István Kiss, Ádám Németh, Sándor Szabados, Zénó Ajtay

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Urinary biomarkers might provide non-invasive tool for monitoring of systemic processes. We aimed to investigate the time-course of urinary orosomucoid (u-ORM) excretion after cardiac surgery hypothesizing that u-ORM is an early and sensitive marker of systemic inflammatory activation. Methods During a 5-day follow-up study we monitored u-ORM levels in cardiovascular patients who underwent on-pump cardiac surgery (n = 38). The patients baseline data were compared to healthy control individuals (n = 40). u-ORM was measured by a newly developed automated turbidimetric assay and values were referred to urinary creatinine and expressed as u-ORM/u-CREAT (mg/mmol). Results The cardiovascular patients showed slightly increased baseline u-ORM excretion compared to healthy controls (0.29 vs 0.08 mg/mmol, p < 0.001). After cardiac surgery, a rapid 10-fold elevation in u-ORM/u-CREAT levels was found. The values remained high till the 3rd postoperative day, and they then decreased significantly (p < 0.01) on the 5th day after surgery. u-ORM/u-CREAT mirrored well the perioperative tendency of hs-CRP levels, but it did not follow the non-decreasing kinetics of serum ORM concentrations during the follow-up. u-ORM/u-CREAT correlated significantly (p < 0.001) with inflammatory parameters (hs-CRP, se-ORM, WBC). Conclusions We described u-ORM as an early and sensitive marker of inflammatory activation. The rapid elevation of u-ORM/u-CREAT after surgery and its postoperative kinetics could reflect the magnitude of inflammatory response better than serum ORM and similar to hs-CRP. u-ORM measurements might provide a novel non-invasive tool for real-time monitoring of systemic inflammation, however further investigations are required to confirm it.

Original languageEnglish
Pages (from-to)1002-1006
Number of pages5
JournalClinical Biochemistry
Volume50
Issue number18
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Orosomucoid
Surgery
Thoracic Surgery
Monitoring
Chemical activation
Kinetics
Biomarkers
Serum
Ambulatory Surgical Procedures
Assays
Creatinine

Keywords

  • Biomarker
  • Cardiopulmonary bypass
  • Inflammation
  • Urine
  • α1-Acid glycoprotein

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Monitoring urinary orosomucoid in patients undergoing cardiac surgery : A promising novel inflammatory marker. / Kustán, Péter; Szirmay, Balázs; Kőszegi, T.; Ludány, Andrea; Kovács, G.; Miseta, A.; Mühl, Diána; Németh, Balázs; Kiss, István; Németh, Ádám; Szabados, Sándor; Ajtay, Zénó.

In: Clinical Biochemistry, Vol. 50, No. 18, 01.12.2017, p. 1002-1006.

Research output: Contribution to journalArticle

Kustán, P, Szirmay, B, Kőszegi, T, Ludány, A, Kovács, G, Miseta, A, Mühl, D, Németh, B, Kiss, I, Németh, Á, Szabados, S & Ajtay, Z 2017, 'Monitoring urinary orosomucoid in patients undergoing cardiac surgery: A promising novel inflammatory marker', Clinical Biochemistry, vol. 50, no. 18, pp. 1002-1006. https://doi.org/10.1016/j.clinbiochem.2017.07.010
Kustán, Péter ; Szirmay, Balázs ; Kőszegi, T. ; Ludány, Andrea ; Kovács, G. ; Miseta, A. ; Mühl, Diána ; Németh, Balázs ; Kiss, István ; Németh, Ádám ; Szabados, Sándor ; Ajtay, Zénó. / Monitoring urinary orosomucoid in patients undergoing cardiac surgery : A promising novel inflammatory marker. In: Clinical Biochemistry. 2017 ; Vol. 50, No. 18. pp. 1002-1006.
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