Monitoring the pharmacokinetics of pyridinium aldoximes in the body

H. Kalász, J. Furész, K. Tekes

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.

Original languageEnglish
Pages (from-to)596-610
Number of pages15
JournalMini-Reviews in Medicinal Chemistry
Volume9
Issue number5
DOIs
Publication statusPublished - 2009

Fingerprint

Oximes
Organophosphates
Pharmacokinetics
Organophosphate Poisoning
Antidotes
Cholinesterases
Blood-Brain Barrier
Agriculture
Human Body
Pharmacology
Health
Enzymes
Warfare

Keywords

  • K-203
  • K-27
  • K-48
  • Pralidoxime
  • Pyridinium aldoximes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Monitoring the pharmacokinetics of pyridinium aldoximes in the body. / Kalász, H.; Furész, J.; Tekes, K.

In: Mini-Reviews in Medicinal Chemistry, Vol. 9, No. 5, 2009, p. 596-610.

Research output: Contribution to journalArticle

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