Monitoring the metabolism of moexipril to moexiprilat using high-performance liquid chromatography-electrospray ionization mass spectrometry

J. Kóti, V. Háda, G. Petroianu, M. Y. Hasan, K. Tekes, Z. Szücs, H. Kalász

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

High-performance liquid chromatography combined with a UV absorbance detector and electrospray ionization mass spectrometer is used for the simultaneous analysis of moexipril and moexiprilat in biological samples. Moexipril and moexiprilat are determined in samples metabolized by rat and human liver microsomal preparations, and also in rat urine. The calibration curve is linear in the ng/mL and μg/mL concentration range of the injected moexipril.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalJournal of chromatographic science
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 2006

    Fingerprint

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this