Monitoring platelet function by PFA-100 closure time measurements during thrombolytic therapy of patients with myocardial infarction

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Abstract

Impaired platelet function plays a major role in the bleeding episodes during thrombolysis, while thrombolysis-induced platelet activation might contribute to the reocclusion process. The purpose of our study was to evaluate if PFA-100, a new platelet function analyzer, could be used for monitoring platelet function during thrombolysis. CADP and CEPI closure times of 33 patients with MI were measured before, 2 and 4-6 h after the initiation of thrombolytic therapy and the addition of ASA. In one-third of the patients, CADP closure time became prolonged during thrombolytic therapy indicating impairment of platelet function. The effect of ASA treatment was monitored by the prolongation of CEPI closure time. Only two-thirds of the MI patients showed adequate response to ASA during thrombolysis. In three patients being on long-term ASA therapy prior to the onset of MI, a temporary decrease of the originally highly prolonged closure time was observed. The results suggest that measurement of PFA-100 closure times is a useful tool for monitoring platelet function during thrombolytic therapy. It also provides information on the effectiveness of ASA administered before or during thrombolysis.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalThrombosis Research
Volume116
Issue number2
DOIs
Publication statusPublished - 2005

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Thrombolytic Therapy
Blood Platelets
Myocardial Infarction
Platelet Activation
Hemorrhage
Therapeutics

Keywords

  • Acetylsalicylic acid
  • Myocardial infarction
  • PFA-100
  • Platelets
  • Streptokinase
  • Thrombolysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

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title = "Monitoring platelet function by PFA-100 closure time measurements during thrombolytic therapy of patients with myocardial infarction",
abstract = "Impaired platelet function plays a major role in the bleeding episodes during thrombolysis, while thrombolysis-induced platelet activation might contribute to the reocclusion process. The purpose of our study was to evaluate if PFA-100, a new platelet function analyzer, could be used for monitoring platelet function during thrombolysis. CADP and CEPI closure times of 33 patients with MI were measured before, 2 and 4-6 h after the initiation of thrombolytic therapy and the addition of ASA. In one-third of the patients, CADP closure time became prolonged during thrombolytic therapy indicating impairment of platelet function. The effect of ASA treatment was monitored by the prolongation of CEPI closure time. Only two-thirds of the MI patients showed adequate response to ASA during thrombolysis. In three patients being on long-term ASA therapy prior to the onset of MI, a temporary decrease of the originally highly prolonged closure time was observed. The results suggest that measurement of PFA-100 closure times is a useful tool for monitoring platelet function during thrombolytic therapy. It also provides information on the effectiveness of ASA administered before or during thrombolysis.",
keywords = "Acetylsalicylic acid, Myocardial infarction, PFA-100, Platelets, Streptokinase, Thrombolysis",
author = "Adrienne Ker{\'e}nyi and P. Solt{\'e}sz and K. Veres and G. Szegedi and L. Muszbek",
year = "2005",
doi = "10.1016/j.thromres.2004.10.003",
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AU - Kerényi, Adrienne

AU - Soltész, P.

AU - Veres, K.

AU - Szegedi, G.

AU - Muszbek, L.

PY - 2005

Y1 - 2005

N2 - Impaired platelet function plays a major role in the bleeding episodes during thrombolysis, while thrombolysis-induced platelet activation might contribute to the reocclusion process. The purpose of our study was to evaluate if PFA-100, a new platelet function analyzer, could be used for monitoring platelet function during thrombolysis. CADP and CEPI closure times of 33 patients with MI were measured before, 2 and 4-6 h after the initiation of thrombolytic therapy and the addition of ASA. In one-third of the patients, CADP closure time became prolonged during thrombolytic therapy indicating impairment of platelet function. The effect of ASA treatment was monitored by the prolongation of CEPI closure time. Only two-thirds of the MI patients showed adequate response to ASA during thrombolysis. In three patients being on long-term ASA therapy prior to the onset of MI, a temporary decrease of the originally highly prolonged closure time was observed. The results suggest that measurement of PFA-100 closure times is a useful tool for monitoring platelet function during thrombolytic therapy. It also provides information on the effectiveness of ASA administered before or during thrombolysis.

AB - Impaired platelet function plays a major role in the bleeding episodes during thrombolysis, while thrombolysis-induced platelet activation might contribute to the reocclusion process. The purpose of our study was to evaluate if PFA-100, a new platelet function analyzer, could be used for monitoring platelet function during thrombolysis. CADP and CEPI closure times of 33 patients with MI were measured before, 2 and 4-6 h after the initiation of thrombolytic therapy and the addition of ASA. In one-third of the patients, CADP closure time became prolonged during thrombolytic therapy indicating impairment of platelet function. The effect of ASA treatment was monitored by the prolongation of CEPI closure time. Only two-thirds of the MI patients showed adequate response to ASA during thrombolysis. In three patients being on long-term ASA therapy prior to the onset of MI, a temporary decrease of the originally highly prolonged closure time was observed. The results suggest that measurement of PFA-100 closure times is a useful tool for monitoring platelet function during thrombolytic therapy. It also provides information on the effectiveness of ASA administered before or during thrombolysis.

KW - Acetylsalicylic acid

KW - Myocardial infarction

KW - PFA-100

KW - Platelets

KW - Streptokinase

KW - Thrombolysis

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