Monitoring of skin penetration and absorption with a new in vivo experimental model

Szilvia Berkó, Boglárka Balázs, Blanka Sütő, Gábor Erős, Brigitta Gál, Anita Sztojkov-Ivanov, Codruța Soica, P. Szabó-Révész, L. Kemény, I. Zupkó, Erzsébet Csányi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The purpose of the study was to use a new type of in vivo animal model developed by our research group for the investigation of skin penetration, compared to the results of Franz cell measurements. The new in vivo experimental model provides possibility for the exact measurement of the quantity of the penetrated drug through the living mouse skin. Two gel formulations containing ibuprofen were investigated with or without penetration enhancer. The applied penetration enhancer was Transcutol®. The effect of the penetration enhancer was clearly detected in both models. The in vitro diffused amount of ibuprofen was significantly higher than the one permeated through the living skin. The presence of the active agent in the plasma was also determined after the observation period. It was possible to monitor the penetration and absorption of topical formulations simultaneously.

Original languageEnglish
Pages (from-to)1157-1163
Number of pages7
JournalFarmacia
Volume62
Issue number6
Publication statusPublished - 2014

Fingerprint

Skin Absorption
Theoretical Models
Ibuprofen
Skin
Animal Models
Gels
Observation
Research
Pharmaceutical Preparations

Keywords

  • Franz-cell
  • Ibuprofen
  • Skin permeation
  • Skinfold model
  • Transcutol®

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Berkó, S., Balázs, B., Sütő, B., Erős, G., Gál, B., Sztojkov-Ivanov, A., ... Csányi, E. (2014). Monitoring of skin penetration and absorption with a new in vivo experimental model. Farmacia, 62(6), 1157-1163.

Monitoring of skin penetration and absorption with a new in vivo experimental model. / Berkó, Szilvia; Balázs, Boglárka; Sütő, Blanka; Erős, Gábor; Gál, Brigitta; Sztojkov-Ivanov, Anita; Soica, Codruța; Szabó-Révész, P.; Kemény, L.; Zupkó, I.; Csányi, Erzsébet.

In: Farmacia, Vol. 62, No. 6, 2014, p. 1157-1163.

Research output: Contribution to journalArticle

Berkó, S, Balázs, B, Sütő, B, Erős, G, Gál, B, Sztojkov-Ivanov, A, Soica, C, Szabó-Révész, P, Kemény, L, Zupkó, I & Csányi, E 2014, 'Monitoring of skin penetration and absorption with a new in vivo experimental model', Farmacia, vol. 62, no. 6, pp. 1157-1163.
Berkó S, Balázs B, Sütő B, Erős G, Gál B, Sztojkov-Ivanov A et al. Monitoring of skin penetration and absorption with a new in vivo experimental model. Farmacia. 2014;62(6):1157-1163.
Berkó, Szilvia ; Balázs, Boglárka ; Sütő, Blanka ; Erős, Gábor ; Gál, Brigitta ; Sztojkov-Ivanov, Anita ; Soica, Codruța ; Szabó-Révész, P. ; Kemény, L. ; Zupkó, I. ; Csányi, Erzsébet. / Monitoring of skin penetration and absorption with a new in vivo experimental model. In: Farmacia. 2014 ; Vol. 62, No. 6. pp. 1157-1163.
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