Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing

R. Horváth, Henrik C. Pedersen, Nina Skivesen, David Selmeczi, Niels B. Larsen

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The effect of the attachment and spreading of living cells on the modes of a grating coupled reverse symmetry waveguide sensor is investigated in real time. The reverse symmetry design has an increased probing depth into the sample making it well suited for the monitoring of cell morphology. As a result, significant changes in the incoupling peak height and peak shape were observed during cell attachment and spreading. It is suggested that the area under the incoupling peaks reflects the initial cell attachment process, while the mean peak position is mostly governed by the spreading of the cells.

Original languageEnglish
Article number071101
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Volume86
Issue number7
DOIs
Publication statusPublished - Feb 14 2005

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attachment
waveguides
symmetry
cells
gratings
sensors

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing. / Horváth, R.; Pedersen, Henrik C.; Skivesen, Nina; Selmeczi, David; Larsen, Niels B.

In: Applied Physics Letters, Vol. 86, No. 7, 071101, 14.02.2005, p. 1-3.

Research output: Contribution to journalArticle

Horváth, R. ; Pedersen, Henrik C. ; Skivesen, Nina ; Selmeczi, David ; Larsen, Niels B. / Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing. In: Applied Physics Letters. 2005 ; Vol. 86, No. 7. pp. 1-3.
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