Molecules acting on receptor level at weaning, durably influence liver glucocorticoid receptors

G. Csaba, Ágnes Inczefi-Gonda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the experiments the effect of late hormonal imprinting to the liver glucocorticoid receptors were studied. Three-week-old (weanling) female rats were treated with five molecules acting at receptor level and four weeks later receptor kinetic analysis was done on liver glucocorticoid receptors. The tricyclic antidepressant, histamine and serotonin receptor blocker mianserin positively influenced receptor density and negatively receptor affinity. Vitamin D3 and the environmental pollutant benzpyrene elevated receptor density. Mifepristone (RU 486) which is bound by progesterone- and glucorticoid-receptor without postreceptorial effects was ineffective as well, as the H1 receptor blocker chlorpheniramine. The results demonstrate that receptor-level-acting foreign molecules can durably influence the binding capacity of glucocorticoid receptors, however, this is not a general phenomenon and it is not dependent on the type of receptors (membrane or cytosol). Those molecules were effective which 1. have receptor in the same receptor family (vitamin D3) and have postreceptorial effect, or 2. have a structure similar to steroids (benzpyrene) or 3. deeply influenced steroid receptors in earlier experiments (mianserin). This effect should be considered before administering such type of medicaments.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalActa Physiologica Hungarica
Volume92
Issue number1
DOIs
Publication statusPublished - 2005

Fingerprint

Glucocorticoid Receptors
Benzopyrenes
Weaning
Mianserin
Mifepristone
Liver
Chlorpheniramine
Histamine Receptors
Histamine H1 Receptors
Environmental Pollutants
Serotonin Antagonists
Calcitriol Receptors
Steroid Receptors
Cholecalciferol
Tricyclic Antidepressive Agents
Progesterone Receptors
Cytosol
Steroids
Membranes

Keywords

  • Antidepressant
  • Antihistamine
  • Late imprinting
  • Serotonin antagonist
  • Steroid receptors

ASJC Scopus subject areas

  • Physiology

Cite this

Molecules acting on receptor level at weaning, durably influence liver glucocorticoid receptors. / Csaba, G.; Inczefi-Gonda, Ágnes.

In: Acta Physiologica Hungarica, Vol. 92, No. 1, 2005, p. 33-38.

Research output: Contribution to journalArticle

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