Molecular study of the sodium-iodide symporter (NIS): A new field in thyroidology

Orsolya Dohan, Antonio De La Vieja, Nancy Carrasco

Research output: Contribution to journalReview article

40 Citations (Scopus)


The active transport of iodide into the thyroid is mediated by the Na+- I- symporter (NIS), an intrinsic membrane protein. NIS plays key roles in thyroid pathophysiology as the route by which I- reaches the gland for thyroid hormone biosynthesis, and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in thyroid cancer. The molecular characterization of NIS started with the isolation in 1996 of a cDNA encoding rat NIS, and has subsequently led to a virtually new field in thyroidology. The research reviewed in this article clearly has far-reaching implications in the areas of structure/function of transport proteins, thyroid pathophysiology, hormone action mechanisms, cell differentiation and cancer.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalTrends in Endocrinology and Metabolism
Issue number3
Publication statusPublished - Apr 1 2000

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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