Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

M. Szücs, H. A. Oktem, V. Szűts, I. Lengyel, G. Toth, C. J. Coscia, M. Wollemann

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.

Original languageEnglish
Title of host publicationNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages250
Number of pages1
ISBN (Print)044481213X
Publication statusPublished - 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

Fingerprint

mu Opioid Receptor
Molecular Structure
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Light
Membranes
Guanosine Triphosphate
Molecular Weight
Binding Sites
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szücs, M., Oktem, H. A., Szűts, V., Lengyel, I., Toth, G., Coscia, C. J., & Wollemann, M. (1990). Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, ... T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 250). Elsevier Science Publishers B.V..

Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. / Szücs, M.; Oktem, H. A.; Szűts, V.; Lengyel, I.; Toth, G.; Coscia, C. J.; Wollemann, M.

New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. p. 250.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Szücs, M, Oktem, HA, Szűts, V, Lengyel, I, Toth, G, Coscia, CJ & Wollemann, M 1990, Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V., pp. 250, The International Narcotics Research Conference, 7/8/89.
Szücs M, Oktem HA, Szűts V, Lengyel I, Toth G, Coscia CJ et al. Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. p. 250
Szücs, M. ; Oktem, H. A. ; Szűts, V. ; Lengyel, I. ; Toth, G. ; Coscia, C. J. ; Wollemann, M. / Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. pp. 250
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