Molecular structure of transient receptor potential vanilloid type 1 ion channel (TRPV1)

Laszlo Urban, John P M White, I. Nagy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Elaboration of the structure of TRPV1 and its functional relationship with channel activity is a work in progress, with much remaining to be done before the structure-function relationship of TRPV1 is comprehensively elicited. The result is that the present state of knowledge can reasonably be described as a patch-work of insightful data where major deficits in knowledge remain and where meaningful general conclusions cannot be reliably drawn. This is unfortunate, given that this ion channel has been convincingly implicated in a wide range of physiological functions and pathological conditions. Moreover, the development of therapeutic strategies which target TRPV1 depends on the knowledge of this receptor's structure and its relationship with channel function. Here, we offer a description of the present state of knowledge in relation to this complex subject.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalCurrent Pharmaceutical Biotechnology
Volume12
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Molecular Structure
Ion Channels
vanilloid receptor subtype 1
Therapeutics

Keywords

  • Capsaicin
  • Channel
  • Pain
  • Receptor
  • Structure
  • TRPV1

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Biotechnology

Cite this

Molecular structure of transient receptor potential vanilloid type 1 ion channel (TRPV1). / Urban, Laszlo; White, John P M; Nagy, I.

In: Current Pharmaceutical Biotechnology, Vol. 12, No. 1, 2011, p. 115-121.

Research output: Contribution to journalArticle

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