Molecular structure and function of biological barriers

I. Krizbai, Csilla Fazakas, János Haskó, Judit Molnár, Ádám Nyúl-Tóth, Attila E. Farkas, I. Wilhelm

Research output: Contribution to journalArticle

Abstract

Biological barriers are indispensable for the integrity and function of many vertebrate organs. The barrier function is based on intercellular protein complexes of the plasma membrane which form paracellular diffusion barriers and separate internal and external fluid compartments, an indispensable prerequisite for every organ development and function. The review summarizes key characteristics and molecular structure of intercellular junctions (tight junctions and adherens junctions) responsible for cellular barrier formation. One of the most important such cellular barriers is the blood-brain barrier (BBB) which forms an active interface between the circulation and neural tissue. Its principal cellular components are cerebral endothelial cells, pericytes and astrocytes, whose finely tuned interactions are needed for a proper function. The review highlights the most important functions of the BBB including some novel regulatory aspects as well.

Original languageEnglish
Pages (from-to)39-50
Number of pages12
JournalActa Biologica Szegediensis
Volume59
Publication statusPublished - 2015

Fingerprint

blood-brain barrier
Molecular Structure
Blood-Brain Barrier
chemical structure
Molecular structure
intercellular junctions
Adherens Junctions
Pericytes
Intercellular Junctions
tight junctions
Tight Junctions
astrocytes
Astrocytes
endothelial cells
Vertebrates
nerve tissue
plasma membrane
Endothelial Cells
vertebrates
Cell Membrane

Keywords

  • Blood-brain barrier
  • Endothelial cells
  • Epithelial cells
  • Tight junctions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Krizbai, I., Fazakas, C., Haskó, J., Molnár, J., Nyúl-Tóth, Á., Farkas, A. E., & Wilhelm, I. (2015). Molecular structure and function of biological barriers. Acta Biologica Szegediensis, 59, 39-50.

Molecular structure and function of biological barriers. / Krizbai, I.; Fazakas, Csilla; Haskó, János; Molnár, Judit; Nyúl-Tóth, Ádám; Farkas, Attila E.; Wilhelm, I.

In: Acta Biologica Szegediensis, Vol. 59, 2015, p. 39-50.

Research output: Contribution to journalArticle

Krizbai, I, Fazakas, C, Haskó, J, Molnár, J, Nyúl-Tóth, Á, Farkas, AE & Wilhelm, I 2015, 'Molecular structure and function of biological barriers', Acta Biologica Szegediensis, vol. 59, pp. 39-50.
Krizbai I, Fazakas C, Haskó J, Molnár J, Nyúl-Tóth Á, Farkas AE et al. Molecular structure and function of biological barriers. Acta Biologica Szegediensis. 2015;59:39-50.
Krizbai, I. ; Fazakas, Csilla ; Haskó, János ; Molnár, Judit ; Nyúl-Tóth, Ádám ; Farkas, Attila E. ; Wilhelm, I. / Molecular structure and function of biological barriers. In: Acta Biologica Szegediensis. 2015 ; Vol. 59. pp. 39-50.
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