Molecular Recognition Using Foldamers

Z. Hegedüs, T. Martinek

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Self-organizing polymers (foldamers) that are capable of controlled molecular recognition are extensively investigated in supramolecular chemistry. The predictable shape and the modular synthesis of foldamers make them excellent tools with which to design and construct complementary interaction surfaces required for molecular recognition. The appropriate choice of monomeric unit patterns can lead to oligomers that recognize diverse interaction partners: cavities for small-molecule entrapment or the projection of functional groups from a well-defined scaffold to mimic complex structures such as protein surfaces. The construction of foldamers for protein recognition is a very attractive strategy for medicinal chemistry applications with promising results. In this article, foldamers that recognize small molecules, biomacromolecules, and membranes will be addressed with a brief general review of the structures and design strategies.

Original languageEnglish
Title of host publicationBioinspired and Biomimetic Supramolecular Chemistry
PublisherElsevier Inc.
Pages511-537
Number of pages27
Volume4
ISBN (Electronic)9780128031988
ISBN (Print)9780128031995
DOIs
Publication statusPublished - Jun 22 2017

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Keywords

  • Aromatic oligoamides
  • Azapeptides
  • Foldamers
  • Helix
  • Membrane-interacting foldamers
  • Molecular capsules
  • Nucleic acids
  • Oligoureas
  • Peptides
  • Peptoids
  • Protein mimetics
  • Protein-protein interactions
  • Secondary structure
  • Sheet
  • β-Peptides

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Hegedüs, Z., & Martinek, T. (2017). Molecular Recognition Using Foldamers. In Bioinspired and Biomimetic Supramolecular Chemistry (Vol. 4, pp. 511-537). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-409547-2.12547-8