Molecular pathways and pathomorphology of colorectal cancers

Erika Tóth, Orsolya Serester, M. Gallai, Simona Gurzu, I. Jung, Z. Szentirmay

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Colorectal carcinomas (CRCs) evolve through multiple pathways. These pathways may be defined based on two molecular features: (1) chromosomal instability and (2) chromosomal stability. Tumors showing chromosomal stability evolve through the so-called microsatellite instability pathway. These types of tumors show different clinico-pathological features and need different therapy so very important to separate them. As Hematoxylin-Eosin (HE) based histology is influenced by the different genetic alterations of a tumor, it is reasonable that different gene expression profiles result in different HE morphology. Our aim was to find specific histomorphological features specific for colorectal tumors showing different molecular features. We analyzed the clinicopathological parameters of 324 colorectal carcinomas, 26 hereditary non-polyposis colorectal cancers, 32 sporadic high-level microsatellite-instable (MSI-H) cancers and 266 microsatellite-stable or low-level microsatellite-instable (MSI-L) cancers among them. Our results showed that we could recognize different genetic types of tumors on the base of clinicopathological features like patient's age, tumor localization and histological characteristics of CRCs. Main histological parameters help in differentiation are inflammatory background, nuclear features and pattern of infiltration. Clinical parameters like clinical stage and localization and careful histological analysis helps to select molecular method to define molecular features and to select the most appropriate therapy of a given tumor.

Original languageEnglish
Pages (from-to)767-773
Number of pages7
JournalRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Volume52
Issue number3
Publication statusPublished - 2011

Fingerprint

Colorectal Neoplasms
Chromosomal Instability
Neoplasms
Microsatellite Repeats
Hematoxylin
Eosine Yellowish-(YS)
Microsatellite Instability
Transcriptome
Histology
Therapeutics

Keywords

  • Chromosomal instability
  • Chromosomal stability
  • Colorectal carcinoma
  • Microsatellite instability
  • Tumor morphology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Embryology
  • Developmental Biology
  • Cell Biology

Cite this

Molecular pathways and pathomorphology of colorectal cancers. / Tóth, Erika; Serester, Orsolya; Gallai, M.; Gurzu, Simona; Jung, I.; Szentirmay, Z.

In: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, Vol. 52, No. 3, 2011, p. 767-773.

Research output: Contribution to journalArticle

@article{e5ba55b56d3d4651802e9bd5e538f0e9,
title = "Molecular pathways and pathomorphology of colorectal cancers",
abstract = "Colorectal carcinomas (CRCs) evolve through multiple pathways. These pathways may be defined based on two molecular features: (1) chromosomal instability and (2) chromosomal stability. Tumors showing chromosomal stability evolve through the so-called microsatellite instability pathway. These types of tumors show different clinico-pathological features and need different therapy so very important to separate them. As Hematoxylin-Eosin (HE) based histology is influenced by the different genetic alterations of a tumor, it is reasonable that different gene expression profiles result in different HE morphology. Our aim was to find specific histomorphological features specific for colorectal tumors showing different molecular features. We analyzed the clinicopathological parameters of 324 colorectal carcinomas, 26 hereditary non-polyposis colorectal cancers, 32 sporadic high-level microsatellite-instable (MSI-H) cancers and 266 microsatellite-stable or low-level microsatellite-instable (MSI-L) cancers among them. Our results showed that we could recognize different genetic types of tumors on the base of clinicopathological features like patient's age, tumor localization and histological characteristics of CRCs. Main histological parameters help in differentiation are inflammatory background, nuclear features and pattern of infiltration. Clinical parameters like clinical stage and localization and careful histological analysis helps to select molecular method to define molecular features and to select the most appropriate therapy of a given tumor.",
keywords = "Chromosomal instability, Chromosomal stability, Colorectal carcinoma, Microsatellite instability, Tumor morphology",
author = "Erika T{\'o}th and Orsolya Serester and M. Gallai and Simona Gurzu and I. Jung and Z. Szentirmay",
year = "2011",
language = "English",
volume = "52",
pages = "767--773",
journal = "Romanian Journal of Morphology and Embryology",
issn = "1220-0522",
publisher = "Editura Academiei Romane",
number = "3",

}

TY - JOUR

T1 - Molecular pathways and pathomorphology of colorectal cancers

AU - Tóth, Erika

AU - Serester, Orsolya

AU - Gallai, M.

AU - Gurzu, Simona

AU - Jung, I.

AU - Szentirmay, Z.

PY - 2011

Y1 - 2011

N2 - Colorectal carcinomas (CRCs) evolve through multiple pathways. These pathways may be defined based on two molecular features: (1) chromosomal instability and (2) chromosomal stability. Tumors showing chromosomal stability evolve through the so-called microsatellite instability pathway. These types of tumors show different clinico-pathological features and need different therapy so very important to separate them. As Hematoxylin-Eosin (HE) based histology is influenced by the different genetic alterations of a tumor, it is reasonable that different gene expression profiles result in different HE morphology. Our aim was to find specific histomorphological features specific for colorectal tumors showing different molecular features. We analyzed the clinicopathological parameters of 324 colorectal carcinomas, 26 hereditary non-polyposis colorectal cancers, 32 sporadic high-level microsatellite-instable (MSI-H) cancers and 266 microsatellite-stable or low-level microsatellite-instable (MSI-L) cancers among them. Our results showed that we could recognize different genetic types of tumors on the base of clinicopathological features like patient's age, tumor localization and histological characteristics of CRCs. Main histological parameters help in differentiation are inflammatory background, nuclear features and pattern of infiltration. Clinical parameters like clinical stage and localization and careful histological analysis helps to select molecular method to define molecular features and to select the most appropriate therapy of a given tumor.

AB - Colorectal carcinomas (CRCs) evolve through multiple pathways. These pathways may be defined based on two molecular features: (1) chromosomal instability and (2) chromosomal stability. Tumors showing chromosomal stability evolve through the so-called microsatellite instability pathway. These types of tumors show different clinico-pathological features and need different therapy so very important to separate them. As Hematoxylin-Eosin (HE) based histology is influenced by the different genetic alterations of a tumor, it is reasonable that different gene expression profiles result in different HE morphology. Our aim was to find specific histomorphological features specific for colorectal tumors showing different molecular features. We analyzed the clinicopathological parameters of 324 colorectal carcinomas, 26 hereditary non-polyposis colorectal cancers, 32 sporadic high-level microsatellite-instable (MSI-H) cancers and 266 microsatellite-stable or low-level microsatellite-instable (MSI-L) cancers among them. Our results showed that we could recognize different genetic types of tumors on the base of clinicopathological features like patient's age, tumor localization and histological characteristics of CRCs. Main histological parameters help in differentiation are inflammatory background, nuclear features and pattern of infiltration. Clinical parameters like clinical stage and localization and careful histological analysis helps to select molecular method to define molecular features and to select the most appropriate therapy of a given tumor.

KW - Chromosomal instability

KW - Chromosomal stability

KW - Colorectal carcinoma

KW - Microsatellite instability

KW - Tumor morphology

UR - http://www.scopus.com/inward/record.url?scp=80052783161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052783161&partnerID=8YFLogxK

M3 - Article

C2 - 21892517

AN - SCOPUS:80052783161

VL - 52

SP - 767

EP - 773

JO - Romanian Journal of Morphology and Embryology

JF - Romanian Journal of Morphology and Embryology

SN - 1220-0522

IS - 3

ER -