Molecular pathology of tumor metastasis III. Target array and combinatorial therapies

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Abstract

Therapy of tumor progression and the metastatic disease is the biggest challenge of clinical oncology. Discovery of the diverse molecular pathways behind this complex disease outlined an approach to better treatment strategies. The development of combined cytotoxic treatment protocols has produced promising results but no breakthrough in the clinical management of metastatic disease. The multiple - specific and non-specific - pathways and cellular targets of tumor progression are outlined in this review. Such an approach, individually designed for various cancer types, may have a better chance to treat or even cure cancer patients with progressive disease.

Original languageEnglish
Pages (from-to)49-72
Number of pages24
JournalPathology and Oncology Research
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

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Keywords

  • Cancer cell
  • Host cell
  • Metastasis therapy
  • Molecular target

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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