A krónikus mieloid leukémia molekuláris monitorozásának aktuális kérdései

Translated title of the contribution: Molecular monitoring of myeloid leukemia

Richárd Kiss, Attila Péter Király, Júlia Gaál-Weisinger, Dóra Marosvári, Péter Ambrus Gángó, J. Demeter, Csaba Bödör

Research output: Contribution to journalArticle

Abstract

The last fifteen years brought a revolution both in treatment and diagnostics of chronic myeloid leukemia. Nowadays, the main method for monitoring of the disease is molecular monitoring with real-time PCR technology which can indicate treatment modification. With the development of the international scale and inter-laboratory standardization the residual tumor mass can be measured accurately and the results are comparable between the different laboratories. By the growing experience in the field of molecular responses we can now accurately predict treatment outcome early on with the so called early molecular response and BCR-ABL1 kinetics, allowing the selection of the best TKI with the treatment-free remission representing real option of the near future. Nevertheless, further advancements can be expected, including the workflow automatization and detection of even deeper molecular responses.

Translated title of the contributionMolecular monitoring of myeloid leukemia
Original languageHungarian
Pages (from-to)57-66
Number of pages10
JournalMagyar onkologia
Volume61
Issue number1
Publication statusPublished - Mar 8 2017

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Kiss, R., Király, A. P., Gaál-Weisinger, J., Marosvári, D., Gángó, P. A., Demeter, J., & Bödör, C. (2017). A krónikus mieloid leukémia molekuláris monitorozásának aktuális kérdései. Magyar onkologia, 61(1), 57-66.