Molecular Modeling for Better Understanding of Cucumovirus Pathology

K. Salánki, Ákos Gellért, Katalin Nemes, Zoltán Divéki, E. Balázs

Research output: Contribution to journalArticle

Abstract

Cucumber mosaic virus (CMV) is a small RNA virus capable of infecting a wide variety of plant species. The high economic losses due to the CMV infection made this virus a relevant subject of scientific studies, which were further facilitated by the small size of the viral genome. Hence, CMV also became a model organism to investigate the molecular mechanism of pathogenesis. All viral functions are dependent on intra- and intermolecular interactions between nucleic acids and proteins of the virus and the host. This review summarizes the recent data on molecular determinants of such interactions. A particular emphasis is given to the results obtained by utilizing molecular-based planning and modeling techniques.

Original languageEnglish
JournalAdvances in Virus Research
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Keywords

  • Cucumber mosaic virus
  • Protein interaction
  • Protein modeling
  • Structure and function

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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