Causal link between obesity and type 2 diabetes has already been generally accepted. Alterations in the regulation of central nervous control of food intake, in the adaptive termogenesis and in the endocrinological function of the adipose tissue have foremost importance. Concerning the control of food intake leptin, Agouti-related protein as well as the pro-opiomelanocortin system and its receptors may have pivotal role in developing insulin resistance. In altering the control of adaptive termogenesis leading to obesity and concomittant insulin resistance, the mutations of the β3-adrenergic receptors and the uncoupling proteins are important factors. Key mediators found in adipose tissue regulating insulin sensitivity are the non-esterified fatty acids, components of the turnor necrosis factor system and leptin, with the peroxysome proliferator activating receptor being the main genetic regulator of these adiposity signal molecules.
|Translated title of the contribution||Molecular mechanisms of the link between obesity, insulin resistance and type 2 diabetes|
|Number of pages||9|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Nov 27 2000|
ASJC Scopus subject areas