Az elhizas, az inzulinrezisztencia es a 2-es tipusu diabetes mellitus kapcsolatanak molekularis mechanizmusai

Translated title of the contribution: Molecular mechanisms of the link between obesity, insulin resistance and type 2 diabetes

K. Cseh, F. Salamon, O. Szekeres, G. Speer, J. Toth, G. Winkler

Research output: Contribution to journalArticle

Abstract

Causal link between obesity and type 2 diabetes has already been generally accepted. Alterations in the regulation of central nervous control of food intake, in the adaptive termogenesis and in the endocrinological function of the adipose tissue have foremost importance. Concerning the control of food intake leptin, Agouti-related protein as well as the pro-opiomelanocortin system and its receptors may have pivotal role in developing insulin resistance. In altering the control of adaptive termogenesis leading to obesity and concomittant insulin resistance, the mutations of the β3-adrenergic receptors and the uncoupling proteins are important factors. Key mediators found in adipose tissue regulating insulin sensitivity are the non-esterified fatty acids, components of the turnor necrosis factor system and leptin, with the peroxysome proliferator activating receptor being the main genetic regulator of these adiposity signal molecules.

Original languageHungarian
Pages (from-to)776-784
Number of pages9
JournalLege Artis Medicinae
Volume10
Issue number10
Publication statusPublished - 2000

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Type 2 Diabetes Mellitus
Insulin Resistance
Obesity
Leptin
Adipose Tissue
Agouti-Related Protein
Eating
Pro-Opiomelanocortin
Adiposity
Adrenergic Receptors
Necrosis
Fatty Acids
Mutation
Mitochondrial Uncoupling Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az elhizas, az inzulinrezisztencia es a 2-es tipusu diabetes mellitus kapcsolatanak molekularis mechanizmusai. / Cseh, K.; Salamon, F.; Szekeres, O.; Speer, G.; Toth, J.; Winkler, G.

In: Lege Artis Medicinae, Vol. 10, No. 10, 2000, p. 776-784.

Research output: Contribution to journalArticle

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