Molecular mechanisms of survival strategies in extreme conditions

Salvatore Magazù, Federica Migliardo, Miguel A. Gonzalez, Claudia Mondelli, Stewart F. Parker, B. Vértessy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Today, one of the major challenges in biophysics is to disclose the molecular mechanisms underlying biological processes. In such a frame, the understanding of the survival strategies in extreme conditions received a lot of attention both from the scientific and applicative points of view. Since nature provides precious suggestions to be applied for improving the quality of life, extremophiles are considered as useful model-systems. The main goal of this review is to present an overview of some systems, with a particular emphasis on trehalose playing a key role in several extremophile organisms. The attention is focused on the relation among the structural and dynamic properties of biomolecules and bioprotective mechanisms, as investigated by complementary spectroscopic techniques at low- and high-temperature values.

Original languageEnglish
Pages (from-to)364-376
Number of pages13
JournalLife
Volume2
Issue number4
DOIs
Publication statusPublished - Dec 7 2012

Fingerprint

extremophile
biophysics
Biophysics
Biological Phenomena
Trehalose
Temperature
dynamic property
Biomolecules
trehalose
quality of life
organisms
biological processes
dynamic characteristics
suggestion
temperature
Quality of Life
Extremophiles
extremophiles
methodology

Keywords

  • dUTPase
  • Dynamics
  • Lysozyme
  • Molecular mechanisms
  • Spectroscopic techniques
  • Structure
  • Survival strategies
  • Trehalose

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Palaeontology
  • Space and Planetary Science

Cite this

Magazù, S., Migliardo, F., Gonzalez, M. A., Mondelli, C., Parker, S. F., & Vértessy, B. (2012). Molecular mechanisms of survival strategies in extreme conditions. Life, 2(4), 364-376. https://doi.org/10.3390/life2040364

Molecular mechanisms of survival strategies in extreme conditions. / Magazù, Salvatore; Migliardo, Federica; Gonzalez, Miguel A.; Mondelli, Claudia; Parker, Stewart F.; Vértessy, B.

In: Life, Vol. 2, No. 4, 07.12.2012, p. 364-376.

Research output: Contribution to journalArticle

Magazù, S, Migliardo, F, Gonzalez, MA, Mondelli, C, Parker, SF & Vértessy, B 2012, 'Molecular mechanisms of survival strategies in extreme conditions', Life, vol. 2, no. 4, pp. 364-376. https://doi.org/10.3390/life2040364
Magazù S, Migliardo F, Gonzalez MA, Mondelli C, Parker SF, Vértessy B. Molecular mechanisms of survival strategies in extreme conditions. Life. 2012 Dec 7;2(4):364-376. https://doi.org/10.3390/life2040364
Magazù, Salvatore ; Migliardo, Federica ; Gonzalez, Miguel A. ; Mondelli, Claudia ; Parker, Stewart F. ; Vértessy, B. / Molecular mechanisms of survival strategies in extreme conditions. In: Life. 2012 ; Vol. 2, No. 4. pp. 364-376.
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