Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species

László Maródi, Sophie Cypowyj, Beáta Tóth, Liudmyla Chernyshova, Anne Puel, Jean Laurent Casanova

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Signal transducer and activator of transcription (STAT) proteins are key components of the innate and adaptive immune responses to pathogenic microorganisms. Recent research on primary immunodeficiency disorders and the identification of patients carrying germline mutations in STAT1, STAT3, and STAT5B have highlighted the role of human STATs in host defense against various viruses, bacteria, and fungi. Mutations in STAT1 and STAT3 disrupt various cytokine pathways that control mucocutaneous immunity against Candida species, especially Candida albicans, and Staphylococcus species, especially Staphylococcus aureus. Here we consider inborn errors of immunity arising from mutations in either STAT1 or STAT3 that affect mucocutaneous immunity to Candida and Staphylococcus species.

Original languageEnglish
Pages (from-to)1019-1027
Number of pages9
JournalJournal of Allergy and Clinical Immunology
Volume130
Issue number5
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Candida species
  • IL-17
  • Primary immunodeficiency diseases
  • Staphylococcus species
  • signal transducer and activator of transcription
  • signal transducer and activator of transcription 1 and 3

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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