Molecular mechanisms in the antiproliferative action of quercetin

Bela Csokay, Noemi Prajda, George Weber, Edith Olah

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

A single treatment with quercetin (5.5 μM), a plant flavonoid, activated both apoptosis and differentiation programs in K562 human leukemia cells. K562 cells expressed commitment to apoptosis after 1 h exposure, however, at least 12 h of drug exposure was needed to induce differentiation. Early (1 h) down-regulation of the c-myc and Ki-ras oncogenes and rapid reduction of inositol-1,4,5 trisphosphate (IP3) concentration (IC50 = 9 μM, 1 h incubation) are part of the antiproliferative action of quercetin and appear to relate to induction of differentiation and/or apoptotic program of K562 leukemia cells treated with quercetin.

Original languageEnglish
Pages (from-to)2157-2163
Number of pages7
JournalLife Sciences
Volume60
Issue number24
DOIs
Publication statusPublished - May 9 1997

Keywords

  • IP
  • K562 leukemia cells
  • Ki- ras
  • apoptosis
  • c-myc
  • cell differentiation
  • quercetin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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