Molecular interactions of FDCs with B cells in aging

Andras K. Szakal, Yüksel Aydar, Peter Balogh, John G. Tew

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Follicular dendritic cells (FDCs), as accessory cells to B cells, promote germinal center (GC) development. Age-related defects in the role of FDCs are well documented in vivo. In old mice, FDCs bind fewer immune complexes (ICs) and produce few iccosomes for endocytosis by B cells, antigen processing and presentation to T cells. We recently studied whether these defects are due to changes in the FDC microenvironment or to changes in FDCs and their surface molecules. In vitro evidence suggests that age-related defects in both B cell stimulation via the BCR and co-stimulation via CD21/CD21L are related to IC-trapping by FDCs in vivo - a defect which is repairable, at least, in vitro.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalSeminars in Immunology
Volume14
Issue number4
DOIs
Publication statusPublished - Aug 2002

Keywords

  • Aging
  • B cell
  • CR1,2
  • FDC
  • FcγRII

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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