Molecular interactions between DPPC and morphine derivatives: A DSC and EPR study

M. Budai, Zs Szabó, M. Szögyi, Pál Gróf

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The interaction between different morphine derivatives (morphine, codeine, N-methyl-morphine, N-methyl-codeine) and α-L-dipalmitoyl phosphatidylcholine (DPPC) liposomes was studied with differential scanning calorimetry (DSC) and electron paramagnetic resonance (EPR) spectroscopy. Small unilamellar DPPC-liposomes with the given morphine-derivative were prepared by sonication. The size distribution of liposomes was checked by dynamic light scattering (DLS). The amount of entrapped morphine was determined spectrophotometrically. Our results indicate that the morphine and its derivatives principally interact with the lipid head groups, and this interaction leads to a decrease in the mobility of the polar head groups, especially in case of codeine and N-methyl-codeine.

Original languageEnglish
Pages (from-to)239-250
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume250
Issue number1
DOIs
Publication statusPublished - Jan 2 2003

Keywords

  • Codeine
  • DPPC-liposomes
  • DSC
  • EPR
  • Morphine

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Molecular interactions between DPPC and morphine derivatives: A DSC and EPR study'. Together they form a unique fingerprint.

  • Cite this