A központi idegrendszert érinto családi daganatszindrómák molekuláris háttere

Translated title of the contribution: Molecular genetics of familial tumour syndromes of the central nervous system

Balázs Murnyák, Rita Szepesi, Tibor Hortobágyi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although most of the central nervous system tumours are sporadic, rarely they are associated with familial tumour syndromes. These disorders usually present with an autosomal dominant inheritance and neoplasia develops at younger age than in sporadic cases. Most of these tumours are bilateral, multiplex or multifocal. The causative mutations occur in genes involved in cell cycle regulation, cell growth, differentiation and DNA repair. Studying these hereditary cancer predisposition syndromes associated with nervous system tumours can facilitate the deeper understating of the molecular background of sporadic tumours and the development of novel therapeutic agents. This review is an update on hereditary tumour syndromes with nervous system involvement with emphasis on molecular genetic characteristics and their clinical implications.

Translated title of the contributionMolecular genetics of familial tumour syndromes of the central nervous system
Original languageHungarian
Pages (from-to)171-177
Number of pages7
JournalOrvosi hetilap
Volume156
Issue number5
DOIs
Publication statusPublished - Feb 1 2015

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Molecular genetics of familial tumour syndromes of the central nervous system'. Together they form a unique fingerprint.

  • Cite this