Molecular genetic analysis of HLA-DRB, -DQA, and -DQB polymorphisms in Hungarians and distribution of the DRB1*03 allele in adults and newborns

Éva Varga, Emõke Endreffy, Gabriella Samu, Éva Szekeres, Ferenc Tóth, Olga Bede, Ildikó B. Petri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We describe here the genetic variability of HLA-DRB1, -DQA, and -DQB in 140 healthy individuals from Hungary, including 95 randomly selected adults and 45 newborns. Allele and haplotype frequencies as well as linkage disequilibria were calculated. It was found that HLA-DRB1*11, -DQA1*0501, and -DQB1*0301 predominate in Hungarians. This information may be helpful in the future for HLA and disease association studies. Simultaneously, we observed that the frequency of the DRB1*03 allele differs between adults and newborns. Since it is well known that bearers of HLA-DR3 (and/or B8) antigens may display significant changes in immune parameters, the lower frequency in adults indicates that children with the DR3 antigen are predisposed to immune diseases in adulthood.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalExperimental and Clinical Immunogenetics
Volume13
Issue number3-4
Publication statusPublished - Apr 1 1996

Keywords

  • HLA-DQA alleles
  • HLA-DQB alleles
  • HLA-DRB alleles
  • HLA-DRB1*03 allele
  • Hungarian population
  • Polymerase chain reaction
  • Restriction fragment length polymorphism
  • Sequence-specific primers

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Molecular genetic analysis of HLA-DRB, -DQA, and -DQB polymorphisms in Hungarians and distribution of the DRB1*03 allele in adults and newborns'. Together they form a unique fingerprint.

  • Cite this