Molecular forms of alpha-melanocyte-stimulating hormone in pheochromocytoma tissue

J. Gardi, W. K. Khalil, M. Vecsernyés, L. Gáspár, M. Szécsi, J. Julesz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The molecular forms of alpha-melanocyte-stimulating hormone (MSH) in pheochromocytoma tissues have been characterized using reversed-phase HPLC and radioimmunoassay. Six alpha-MSH-related peptides were detected. Three of the six peaks had elution times identical to those of synthetic desacetyl- alpha-MSH, alpha-MSH and diacetyl-alpha-MSH. The remaining three forms of the alpha-MSH-like immunoreactivity suggest a different processing of proopiomelanocortin in this tissue than in the intermediate lobe of the pituitary gland. Current results confirm that alpha-MSH are present in human pheochromocytoma and suggest that alpha-MSH has role in the pathophysiology of this tissue.

Original languageEnglish
Pages (from-to)71-79
Number of pages9
JournalEndocrine Research
Volume26
Issue number1
Publication statusPublished - 2000

Fingerprint

alpha-MSH
Pheochromocytoma
Intermediate Pituitary Gland
Diacetyl
Pro-Opiomelanocortin
Radioimmunoassay
High Pressure Liquid Chromatography
Peptides

ASJC Scopus subject areas

  • Endocrinology

Cite this

Molecular forms of alpha-melanocyte-stimulating hormone in pheochromocytoma tissue. / Gardi, J.; Khalil, W. K.; Vecsernyés, M.; Gáspár, L.; Szécsi, M.; Julesz, J.

In: Endocrine Research, Vol. 26, No. 1, 2000, p. 71-79.

Research output: Contribution to journalArticle

@article{9a35be0dba4d410698e8848a8243141e,
title = "Molecular forms of alpha-melanocyte-stimulating hormone in pheochromocytoma tissue",
abstract = "The molecular forms of alpha-melanocyte-stimulating hormone (MSH) in pheochromocytoma tissues have been characterized using reversed-phase HPLC and radioimmunoassay. Six alpha-MSH-related peptides were detected. Three of the six peaks had elution times identical to those of synthetic desacetyl- alpha-MSH, alpha-MSH and diacetyl-alpha-MSH. The remaining three forms of the alpha-MSH-like immunoreactivity suggest a different processing of proopiomelanocortin in this tissue than in the intermediate lobe of the pituitary gland. Current results confirm that alpha-MSH are present in human pheochromocytoma and suggest that alpha-MSH has role in the pathophysiology of this tissue.",
author = "J. Gardi and Khalil, {W. K.} and M. Vecserny{\'e}s and L. G{\'a}sp{\'a}r and M. Sz{\'e}csi and J. Julesz",
year = "2000",
language = "English",
volume = "26",
pages = "71--79",
journal = "Endocrine Research",
issn = "0743-5800",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Molecular forms of alpha-melanocyte-stimulating hormone in pheochromocytoma tissue

AU - Gardi, J.

AU - Khalil, W. K.

AU - Vecsernyés, M.

AU - Gáspár, L.

AU - Szécsi, M.

AU - Julesz, J.

PY - 2000

Y1 - 2000

N2 - The molecular forms of alpha-melanocyte-stimulating hormone (MSH) in pheochromocytoma tissues have been characterized using reversed-phase HPLC and radioimmunoassay. Six alpha-MSH-related peptides were detected. Three of the six peaks had elution times identical to those of synthetic desacetyl- alpha-MSH, alpha-MSH and diacetyl-alpha-MSH. The remaining three forms of the alpha-MSH-like immunoreactivity suggest a different processing of proopiomelanocortin in this tissue than in the intermediate lobe of the pituitary gland. Current results confirm that alpha-MSH are present in human pheochromocytoma and suggest that alpha-MSH has role in the pathophysiology of this tissue.

AB - The molecular forms of alpha-melanocyte-stimulating hormone (MSH) in pheochromocytoma tissues have been characterized using reversed-phase HPLC and radioimmunoassay. Six alpha-MSH-related peptides were detected. Three of the six peaks had elution times identical to those of synthetic desacetyl- alpha-MSH, alpha-MSH and diacetyl-alpha-MSH. The remaining three forms of the alpha-MSH-like immunoreactivity suggest a different processing of proopiomelanocortin in this tissue than in the intermediate lobe of the pituitary gland. Current results confirm that alpha-MSH are present in human pheochromocytoma and suggest that alpha-MSH has role in the pathophysiology of this tissue.

UR - http://www.scopus.com/inward/record.url?scp=0033995134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033995134&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 71

EP - 79

JO - Endocrine Research

JF - Endocrine Research

SN - 0743-5800

IS - 1

ER -