Molecular epidemiology of tick-borne encephalitis virus: cross-protection between European and Far Eastern subtypes

H. Holzmann, M. S. Vorobyova, I. P. Ladyzhenskaya, E. Ferenczi, M. Kundi, C. Kunz, F. X. Heinz

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Tick-borne encephalitis virus isolates from widely separated geographic regions of the USSR, six isolates from Hungary and one from France were compared with the European and Far Eastern prototype viruses. Peptide mapping by limited proteolysis yielded similar patterns for five selected isolates from the USSR. All isolates from Hungary and France exhibited the same reactivity pattern with a panel of 16 protein E-specific monoclonal antibodies, whereas 10 out of 12 isolates from the Soviet Union showed minor differences at certain epitopes. However, no correlation between geographic origin of the isolates and their antigenic structure was observed. No statistically significant difference in the degree of protection was detected when mice were immunized with the European prototype vaccine and challenged with three selected Asian isolates and one from the European part of the USSR.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalVaccine
Volume10
Issue number5
DOIs
Publication statusPublished - 1992

Keywords

  • European and Far Eastern subtypes
  • Tick-borne encephalitis virus
  • cross-protection
  • molecular epidemiology

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Molecular epidemiology of tick-borne encephalitis virus: cross-protection between European and Far Eastern subtypes'. Together they form a unique fingerprint.

  • Cite this