Molecular epidemiology of hepatitis C virus genotypes and subtypes among injecting drug users in Hungary

B. Tresó, M. Takács, Á Dencs, M. Dudás, A. Pár, E. Rusvai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of this study was to determine the geographical distribution of hepatitis C virus genotypes/subtypes among people who inject drugs (PWID) recruited at 22 needle exchange sites and drug outpatient services in all seven Planning and Statistical Regions of Hungary. Of 198 such PWID, 147 (74.2%), 45 (22.7%) and six (3.0%) carried genotype 1, 3 or 4, respectively, and 31 (72.1%) of the 43 genotype 1 sequences were of subtype 1a. Genotype 3 was significantly more prevalent in provincial towns than in the capital, Budapest. Injecting for a longer period and an older age both correlated with a higher prevalence of genotype 3, suggesting possible future changes in genotype distribution. The distributions of hepatitis C virus genotypes/subtypes differed significantly between the tested PWID and the general population. The identification of genotype 3 reflected its worldwide occurrence among PWID. Our results underline the importance of genotyping before treatment, especially among people who have ever injected drugs in Hungary.

Original languageEnglish
JournalEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin
Volume18
Issue number47
Publication statusPublished - Nov 2013

Fingerprint

Molecular Epidemiology
Hungary
Drug Users
Hepacivirus
Genotype
Pharmaceutical Preparations
Ambulatory Care
Needles
Economics

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

Cite this

@article{5c9c929cf87444abaea868688a857071,
title = "Molecular epidemiology of hepatitis C virus genotypes and subtypes among injecting drug users in Hungary",
abstract = "The aim of this study was to determine the geographical distribution of hepatitis C virus genotypes/subtypes among people who inject drugs (PWID) recruited at 22 needle exchange sites and drug outpatient services in all seven Planning and Statistical Regions of Hungary. Of 198 such PWID, 147 (74.2{\%}), 45 (22.7{\%}) and six (3.0{\%}) carried genotype 1, 3 or 4, respectively, and 31 (72.1{\%}) of the 43 genotype 1 sequences were of subtype 1a. Genotype 3 was significantly more prevalent in provincial towns than in the capital, Budapest. Injecting for a longer period and an older age both correlated with a higher prevalence of genotype 3, suggesting possible future changes in genotype distribution. The distributions of hepatitis C virus genotypes/subtypes differed significantly between the tested PWID and the general population. The identification of genotype 3 reflected its worldwide occurrence among PWID. Our results underline the importance of genotyping before treatment, especially among people who have ever injected drugs in Hungary.",
author = "B. Tres{\'o} and M. Tak{\'a}cs and {\'A} Dencs and M. Dud{\'a}s and A. P{\'a}r and E. Rusvai",
year = "2013",
month = "11",
language = "English",
volume = "18",
journal = "Eurosurveillance",
issn = "1560-7917",
publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",
number = "47",

}

TY - JOUR

T1 - Molecular epidemiology of hepatitis C virus genotypes and subtypes among injecting drug users in Hungary

AU - Tresó, B.

AU - Takács, M.

AU - Dencs, Á

AU - Dudás, M.

AU - Pár, A.

AU - Rusvai, E.

PY - 2013/11

Y1 - 2013/11

N2 - The aim of this study was to determine the geographical distribution of hepatitis C virus genotypes/subtypes among people who inject drugs (PWID) recruited at 22 needle exchange sites and drug outpatient services in all seven Planning and Statistical Regions of Hungary. Of 198 such PWID, 147 (74.2%), 45 (22.7%) and six (3.0%) carried genotype 1, 3 or 4, respectively, and 31 (72.1%) of the 43 genotype 1 sequences were of subtype 1a. Genotype 3 was significantly more prevalent in provincial towns than in the capital, Budapest. Injecting for a longer period and an older age both correlated with a higher prevalence of genotype 3, suggesting possible future changes in genotype distribution. The distributions of hepatitis C virus genotypes/subtypes differed significantly between the tested PWID and the general population. The identification of genotype 3 reflected its worldwide occurrence among PWID. Our results underline the importance of genotyping before treatment, especially among people who have ever injected drugs in Hungary.

AB - The aim of this study was to determine the geographical distribution of hepatitis C virus genotypes/subtypes among people who inject drugs (PWID) recruited at 22 needle exchange sites and drug outpatient services in all seven Planning and Statistical Regions of Hungary. Of 198 such PWID, 147 (74.2%), 45 (22.7%) and six (3.0%) carried genotype 1, 3 or 4, respectively, and 31 (72.1%) of the 43 genotype 1 sequences were of subtype 1a. Genotype 3 was significantly more prevalent in provincial towns than in the capital, Budapest. Injecting for a longer period and an older age both correlated with a higher prevalence of genotype 3, suggesting possible future changes in genotype distribution. The distributions of hepatitis C virus genotypes/subtypes differed significantly between the tested PWID and the general population. The identification of genotype 3 reflected its worldwide occurrence among PWID. Our results underline the importance of genotyping before treatment, especially among people who have ever injected drugs in Hungary.

UR - http://www.scopus.com/inward/record.url?scp=84888121014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888121014&partnerID=8YFLogxK

M3 - Article

C2 - 24300886

AN - SCOPUS:84888121014

VL - 18

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1560-7917

IS - 47

ER -