Molecular Diversity of Plasma Membrane Ca2+ Transporting ATPases: Their Function Under Normal and Pathological Conditions

Luca Hegedűs, Boglárka Zámbó, Katalin Pászty, Rita Padányi, Karolina Varga, John T. Penniston, Ágnes Enyedi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Plasma membrane Ca2+ transport ATPases (PMCA1-4, ATP2B1-4) are responsible for removing excess Ca2+ from the cell in order to keep the cytosolic Ca2+ ion concentration at the low level essential for normal cell function. While these pumps take care of cellular Ca2+ homeostasis they also change the duration and amplitude of the Ca2+ signal and can create Ca2+ gradients across the cell. This is accomplished by generating more than twenty PMCA variants each having the character – fast or slow response, long or short memory, distinct interaction partners and localization signals – that meets the specific needs of the particular cell-type in which they are expressed. It has become apparent that these pumps are essential to normal tissue development and their malfunctioning can be linked to different pathological conditions such as certain types of neurodegenerative and heart diseases, hearing loss and cancer. In this chapter we summarize the complexity of PMCA regulation and function under normal and pathological conditions with particular attention to recent developments of the field.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages93-129
Number of pages37
DOIs
Publication statusPublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1131
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • ATP2B1-4
  • Actin cytoskeleton
  • Altered expression
  • Alternative splice
  • Ca signal
  • Calmodulin
  • Genetic variation
  • Pathological condition
  • Phosphatidylinositol-45-bisphosphate
  • Plasma membrane Ca ATPase (PMCA)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Hegedűs, L., Zámbó, B., Pászty, K., Padányi, R., Varga, K., Penniston, J. T., & Enyedi, Á. (2020). Molecular Diversity of Plasma Membrane Ca2+ Transporting ATPases: Their Function Under Normal and Pathological Conditions. In Advances in Experimental Medicine and Biology (pp. 93-129). (Advances in Experimental Medicine and Biology; Vol. 1131). Springer New York LLC. https://doi.org/10.1007/978-3-030-12457-1_5