Molecular determinants of heart failure with normal left ventricular ejection fraction

A. Borbély, Z. Papp, I. Édes, Walter J. Paulus

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In population-based studies, heart failure with normal left ventricular (LV) ejection fraction (HFNEF) is now increasingly recognized and referred to as diastolic heart failure. However, the pathogenic mechanisms underlying HFNEF are incompletely understood, mainly because of limited availability of human myocardial biopsy material. Nevertheless, recent studies have examined in vivo hemodynamics, in vitro cardiomyocyte function, myofilamentary protein composition, collagen content and deposition of advanced glycation end products from LV endomyocardial biopsies. These measures were compared between HFNEF patients, subjects without symptoms of heart failure (controls), patients with heart failure and reduced ejection function (HFREF), and patients with HFNEF and HFREF with diabetes mellitus. This article summarizes the various findings of these studies and focuses on the possible correlations among altered LV myocardial structure, cardiomyocyte function, myofilamentary proteins, and extracellular matrices. These findings revealed novel mechanisms responsible for diastolic LV dysfunction, and they have important therapeutic implications, particularly HFNEF, for which a specific heart failure treatment strategy is largely lacking.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalPharmacological Reports
Volume61
Issue number1
Publication statusPublished - 2009

Fingerprint

Stroke Volume
Heart Failure
Cardiac Myocytes
Diastolic Heart Failure
Biopsy
Advanced Glycosylation End Products
Extracellular Matrix Proteins
Left Ventricular Dysfunction
Diabetes Mellitus
Collagen
Hemodynamics
Therapeutics
Population
Proteins

Keywords

  • Cardiomyocytes
  • Diabetes mellitus
  • Diastolic function
  • Fibrosis
  • Heart failure
  • Myofilamentary proteins

ASJC Scopus subject areas

  • Pharmacology

Cite this

Molecular determinants of heart failure with normal left ventricular ejection fraction. / Borbély, A.; Papp, Z.; Édes, I.; Paulus, Walter J.

In: Pharmacological Reports, Vol. 61, No. 1, 2009, p. 139-145.

Research output: Contribution to journalArticle

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