We compared echovirus 11 (E11) strains implicated in a severe epidemic in Hungary in 1989 with the prototype E11 strain Gregory and with other E11 strains, most of which were isolated over the same period in Europe (Finland, The Netherlands, Romania, Russia) from sporadic cases or from environmental water. Partial sequencing indicated that the Hungarian strains were closely related to each other and to most European strains. They were particularly closely related to one Romanian strain associated with a sporadic case of hemiparesis and several Finnish strains isolated from environmental water. Sequencing of the complete genomes of one Hungarian strain, the Romanian strain, and one Finnish strain revealed differences of only a few nucleotides in the 5′ half of the genome, including the 5′ nontranslated region (5′-NTR) and the capsid coding region. However, significant differences were observed in the nucleotide sequences of the 3′ half of the genome (nonstructural viral protein region and 3′-NTR), indicating that these strains evolved recently and independently by genetic recombination with other unknown E11 or enterovirus strains.
- Echovirus 11
- Multisystem hemorrhagic disease
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