Molecular chiral recognition in supercritical solvents

E. Fogassy, Mária Ács, Timea Szili, B. Simándi, János Sawinsky

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The intensity of molecular chiral interactions resulting in differences between physical and chemical properties of diastereomeric molecules is solvent dependent. This difference makes it possible to separate the enantiomers of a given substance by using chiral agents. A solvent of supercritical state was involved to study its influence on molecular chiral recognition. It was observed that the differences between the diastereomers in supercritical CO2 are so big compared to traditional solvents that a novel, more efficient method for optical resolution can be developed, employing a variety of resolution agents in a much wider range than it was previously assumed.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number2
DOIs
Publication statusPublished - Jan 10 1994

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Molecular recognition
Molecular interactions
Enantiomers
Chemical properties
Physical properties
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Molecular chiral recognition in supercritical solvents. / Fogassy, E.; Ács, Mária; Szili, Timea; Simándi, B.; Sawinsky, János.

In: Tetrahedron Letters, Vol. 35, No. 2, 10.01.1994, p. 257-260.

Research output: Contribution to journalArticle

Fogassy, E. ; Ács, Mária ; Szili, Timea ; Simándi, B. ; Sawinsky, János. / Molecular chiral recognition in supercritical solvents. In: Tetrahedron Letters. 1994 ; Vol. 35, No. 2. pp. 257-260.
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