Molecular chaperones in the etiology and therapy of cancer

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Molecular chaperones are ubiquitous, well-conserved proteins that account for 2-5% of all cellular proteins in most cells. The present review summarizes our current knowledge about their involvement in the etiology and therapy of cancer with special emphasis on the expression of chaperones in malignant cells, their role in folding of (proto)oncogene products, cell cycle regulation, cell differentiation and apoptosis, development of metastasis, and their participation in the recognition of malignant cells. We also overview the importance of chaperones in hyperthermia, drug resistance, and recent approaches in chaperone-immunotherapy.

Original languageEnglish
Pages (from-to)316-321
Number of pages6
JournalPathology and Oncology Research
Volume4
Issue number4
Publication statusPublished - 1998

Fingerprint

Molecular Chaperones
Neoplasms
Proto-Oncogenes
Oncogene Proteins
Drug Resistance
Immunotherapy
Cell Differentiation
Cell Cycle
Proteins
Fever
Therapeutics
Apoptosis
Neoplasm Metastasis

Keywords

  • Chaperone
  • Drug resistance
  • Heat shock protein
  • Immunotherapy
  • Metastasis
  • Stress protein

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Molecular chaperones in the etiology and therapy of cancer. / Söti, C.; Csermely, P.

In: Pathology and Oncology Research, Vol. 4, No. 4, 1998, p. 316-321.

Research output: Contribution to journalArticle

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