Molecular chaperones as regulatory elements of cellular networks

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Molecular chaperones help hundreds of signaling molecules to keep their activation-competent state, and regulate various signaling processes ranging from signaling at the plasma membrane to transcription. Besides these specific regulatory roles, recent studies have revealed that chaperones act as genetic buffers stabilizing the phenotypes of various cells and organisms. This may be related to their low affinity for the proteins they interact with, which means that they represent weak links in protein networks. Chaperones may uncouple protein, signaling, membrane, organelle and transcriptional networks during stress, which gives the cell additional protection. The same networks are preferentially remodeled in various diseases and aging, which may help us to design novel therapeutic and anti-aging strategies.

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 2005

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Molecular Chaperones
Cytoprotection
Gene Regulatory Networks
Organelles
Buffers
Membrane Proteins
Cell Membrane
Phenotype
Proteins
Therapeutics
link protein

ASJC Scopus subject areas

  • Cell Biology

Cite this

Molecular chaperones as regulatory elements of cellular networks. / Söti, C.; Pál, C.; Papp, B.; Csermely, P.

In: Current Opinion in Cell Biology, Vol. 17, No. 2, 04.2005, p. 210-215.

Research output: Contribution to journalArticle

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