Though porcine adenoviruses (PAdV) are present in swine populations worldwide, they usually do not cause any disease, or if they do, it only manifests (with the exception of PAdV-4) as a mild diarrhea or mild respiratory signs. The importance of adenoviruses is constantly growing as there is a possibility of developing them into viral vector vaccines against more significant swine pathogens. The author summarizes the brief history of porcine adenoviruses, focusing on the present state of the art. He describes the latest developments in the exploration of the genome of all currently recognized PAdV serotypes. There are several possibilities for the insertion of foreign genes into the adenovirus genome. The most convenient area is the early region 3, a region not essential for virus replication. By deleting this region, the packaging capacity of the virus - usually 5% of the genome - can be substantially increased. Replacing the early region 1 (E1) usually means the loss of ability to replicate in vivo, but special cell lines may be able to support virus growth, as seen with human adenoviruses. An E1 replaced recombinant virus would be very safe because of its inability to generate infectious particles in vivo. The author also mentions some examples, such as transmissible gastroenteritis or classical swine fever, where porcine adenovirus-based recombinant vaccines would be useful. He also describes some of the risks of using live recombinant viruses and the necessity of virological surveys before even starting to design such vaccines.
|Number of pages||6|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Dec 1 1999|
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