Molecular biology of gestational trophoblastic neoplasia: A review

Vilmos Fulop, Samuel C. Mok, Ross S. Berkowitz

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Gestational trophoblastic diseases are interrelated conditions characterized by abnormal growth of chorionic tissues with varying propensities for local invasion and metastases. These diseases are characterized by altered expression of several growth regulatory factors and oncogenes. On the basis of the expression of various oncogenes and growth factors, partial mole appears to be more like normal placenta, while complete mole seems to be more like choriocarcinoma. These results may have both prognostic and therapeutic consequences and provide insight into the relationship between normal placenta and gestational trophoblastic diseases.

Original languageEnglish
Pages (from-to)415-422
Number of pages8
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume49
Issue number6
Publication statusPublished - Jun 1 2004

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Keywords

  • Gestational trophoblastic disease
  • Gonadotropins, chorionic, human
  • Pregnancy, molar
  • Trophoblastic cancer
  • Trophoblastic neoplasms

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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