Molecular biological characterization of adenovirus DNA

G. Berencsi, I. Nász

Research output: Contribution to journalArticle

Abstract

The agarose gel electrophoresis of DNA, the ethidium bromide fluorescence detection of DNA fragments and restriction endonucleases were discovered at the end of the '60s. The methodological progress enabled institutions equipped with less sophisticated technology to achieve also unique experimental and scientific results in the field of viral DNA research. The team working on virus DNA within the adenovirus research group has constructed several new restriction endonuclease maps of the genomes of human and animal adenoviruses; contributed to the methodology of the determination of specific endonuclease sites, and genome polarity; discovered new restriction endonucleases, adenovirus subtypes, new empty capsid, and genome subpopulations; participated in cooperations leading to novel, although hypothetical approaches in AIDS therapy, taxonomic definition of viruses, and evolutionary origins of adenovirus replication and encapsidation strategy.

Original languageEnglish
Pages (from-to)297-304
Number of pages8
JournalActa Microbiologica et Immunologica Hungarica
Volume45
Issue number3-4
Publication statusPublished - 1998

Fingerprint

DNA Restriction Enzymes
Adenoviridae
Genome
DNA
Human Adenoviruses
Replication Origin
DNA Viruses
Ethidium
Agar Gel Electrophoresis
Endonucleases
Capsid
Deoxyribonuclease I
Viral DNA
Research
Acquired Immunodeficiency Syndrome
Fluorescence
Viruses
Technology
Therapeutics

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

Molecular biological characterization of adenovirus DNA. / Berencsi, G.; Nász, I.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 45, No. 3-4, 1998, p. 297-304.

Research output: Contribution to journalArticle

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