Modulation of voltage-activated ion currents on identified neurons of Helix pomatia L. by interleukin-1

A. Szűcs, G. B. Stefano, T. K. Hughes, K. S.-Rózsa

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

1. The effect of interleukin-1 (IL-1) was studied on voltage-activated ion currents of the identified central neurons of Helix pomatia L. using a twomicroelectrode voltage clamp. The voltage-activated inward current (ICa) was decreased, whereas the outward current (Inet K) was increased by IL-1. 2. IL-1 affects both the transient and the delayed rectifying potassium currents. The IL-1 modulatory effect on the voltage-activated ion currents was voltage and dose dependent. The threshold concentration for IL-1 was 2 U/ml. 3. The proposed modulatory effect of IL-1 appears to have more than one site of action on the neuron membrane ion channels. 4. Rabbit anti-human IL-1 polyclonal antiserum eliminated the IL-1 effects on the voltage-activated inward and outward currents. This is the first report demonstrating a direct effect of IL-1 modulation of voltage-activated ion currents on neurons of mollusks.

Original languageEnglish
Pages (from-to)429-438
Number of pages10
JournalCellular and Molecular Neurobiology
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 1992

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Interleukin-1
Ions
Neurons
Ion Channels
Mollusca
Immune Sera
Potassium
Rabbits

Keywords

  • antiserum
  • cytokine
  • Helix neurons
  • immunotransmitter
  • interleukin-1
  • inward-outward currents

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Modulation of voltage-activated ion currents on identified neurons of Helix pomatia L. by interleukin-1. / Szűcs, A.; Stefano, G. B.; Hughes, T. K.; S.-Rózsa, K.

In: Cellular and Molecular Neurobiology, Vol. 12, No. 5, 10.1992, p. 429-438.

Research output: Contribution to journalArticle

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