Modulation of uterine GABAA receptors during gestation and by tetrahydroprogesterone

Maria D. Majewska, George Falkay, Etienne E. Baulieu

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Abstract

Binding of a GABAA receptor agonist, [3H]muscimol, was studied in rat uterine membranes of non-pregnant rats and those at days 15 and 19 of pregnancy. Also, an interaction of the uterine GABAA receptors with tetrahydroprogesterone was examined. At day 15 of gestation [3H]muscimol binding was twice as high as in non-pregnant rats, but at day 19 it was reduced. These changes resulted from an increase of the receptor affinity and decrease of the receptor density, at days 15 and 19, respectively. Since tetrahydroprogesterone, in vitro, also increased [3H]muscimol binding, we propose that this steroid may participate in regulation of uterine function during pregnancy.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalEuropean Journal of Pharmacology
Volume174
Issue number1
DOIs
Publication statusPublished - Dec 12 1989

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Keywords

  • GABA receptors
  • Pregnancy
  • Steroid regulation
  • Uterus

ASJC Scopus subject areas

  • Pharmacology

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