Modulation of the effects of sotalol on Purkinje strand electromechanical characteristics

D. A. Lathrop, A. Varro

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The modulation of the effects of sotalol (30 μM) by two sodium channel blockers, tetrodotoxin (0.07 μM) and lidocaine (50 μM), an by a potassium channel activator, nicorandil (30 μM), were examined. Sotalol alone greatly increased Purkinje fiber transmembrane action potential duration and, in some preparations, induced early afterdepolarizations. Concurrent with the changes in action potential duration, sotalol also increased isolated Purkinje strand developed force paced at slow rates (0.33 Hz). These sotalol-induced alterations of Purkinje strand electromechanical characteristics were similar to those produced by either veratrine (0.6 or 1.0 μg/mL) or by tetraethylammonium (10 mM). The effects of sotalol on action potential duration and force development were reversed by exposure to either tetrodotoxin or nicorandil. Lidocaine also reversed the effects of sotalol on action potential duration and developed force. The sotalol-induced increase in action potential duration and development of early afterdepolarizations may, therefore, be abated by combination with drugs that either block cardiac sodium channels or that increase membrane potassium conductance. Combination with such drugs may help prevent the adverse arrhythmogenic effects of sotalol.

Original languageEnglish
Pages (from-to)1463-1467
Number of pages5
JournalCanadian journal of physiology and pharmacology
Volume67
Issue number11
DOIs
Publication statusPublished - Jan 1 1989

Keywords

  • Action potential duration
  • Force development
  • Lidocaine
  • Nicorandil
  • Sotalol
  • Tetrodotoxin

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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