Modulation of ionotropic glutamate receptor channels

L. Köles, K. Wirkner, P. Illes

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Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory. Its dysfunction can be detected in epilepsy, stroke, neurodegenerative disorders and drug abuse. This paper summarizes the present knowledge on the modulation of glutamate-gated ion channels in the central nervous system by phosphorylation. An inhibitory interaction between adenosine A2A receptors and NMDA receptors in the neostriatum is described as an example, mediated by the phospholipase C/inositol trisphosphate/calmodulin and calmodulin kinase II pathway.

Original languageEnglish
Pages (from-to)925-932
Number of pages8
JournalNeurochemical research
Issue number8-9
Publication statusPublished - Nov 12 2001



  • AMPA receptor
  • Adenosine A receptor
  • Ionotropic glutamate receptors
  • NMDA receptor
  • Phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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